Descrizione:
Position Summary GET PE – Synthetics Drug Product Manufacturing Senior Principal Engineer – responsible for leading technical strategy and design for synthetic drug product manufacturing processes across the global site network.ResponsibilitiesLead the intake, scoping, prioritization, and resolution of synthetic controlled bioburden drug product manufacturing technical requests across global sites.Lead and influence early‑phase process design and domain expertise for oral solid dose (OSD) products, covering both batch and continuous manufacturing platforms and new innovative drug product forms.Lead and influence early‑phase process design and domain expertise for bioavailability enhanced technologies, including amorphous solid dispersions (ASD) with a strong emphasis on spray drying, and other technologies such as Self‑Emulsifying Drug Delivery Systems (SEDDS) and related innovative intermediate formulation approaches.Ensure robust, fit‑for‑purpose process design while promoting standardization and platform approaches when they add value.Provide expert input and alignment on key process, equipment, and technology selection decisions for drug product manufacturing.Actively collaborate with functions such as R&D, MSAT, Quality, EHS and Operations leads across synthetic drug product sites.Find opportunities for harmonization, shared solutions, and best‑practice exchange across the network.Foster a culture of collaboration to reduce duplication, accelerate implementation, and improve speed‑to‑market.Maintain strong connections with industry experts and external networks (e.g., ISPE) to bring innovative manufacturing solutions into the organization.Ensure alignment with enterprise strategies, GMP requirements, and technology llaborate with external manufacturing teams to prioritize support and resolve issues for high‑impact programs and partners.Qualifications – RequiredMinimum Master’s degree in Engineering, Pharmaceutical Sciences, or a related technical field.Minimum 10 years of relevant experience in synthetic controlled bioburden drug product manufacturing, focusing on oral solid dose (OSD) processes and innovative technologies (e.g., semi‑solid).Expertise in bioavailability enhanced technologies, including amorphous solid dispersions (ASD) with deep knowledge of spray drying, and SEDDS or similar formulation approaches.Experience with OSD controlled bioburden manufacturing, including batch and continuous processes and associated equipment.Strong understanding of c GMP environments and regulatory expectations for controlled bioburden drug product manufacturing; aseptic capability is a plus.Proven track record of leading multifunctional teams and influencing technical decisions in complex global organizations.Ability to support early‑phase design, detail design, start‑up processes, and commissioning & qualification (C&Q) of controlled bioburden and aseptic equipment.Experience with inherently safe containment design for components with low exposure level.Drive adoption of digital and data‑enabled solutions for drug product manufacturing, including real‑time monitoring, advanced process control, analytics, modelling, and smart manufacturing use cases.Strong customer management and communication skills, with ability to influence across sites, functions, and external partners.Strategic attitude combined with hands‑on technical capability.Intellectual curiosity to challenge the status quo, influence without authority, and cultivate an inclusive, collaborative culture.Proficiency in written and spoken English.Willingness to travel up to 25% domestically and internationally.PreferredStrategic attitude combined with hands‑on technical capability.Intellectual curiosity to challenge the status quo, influence without authority, and cultivate an inclusive and collaborative culture.Additional languages (Dutch, Spanish, Italian) are an advantage.Required SkillsAgile Decision MakingCoachingConsultingCorrective and Preventive Action (CAPA)Crisis ManagementCross‑Functional CollaborationDisruptive InnovationsEmerging TechnologiesIndustrial HygieneLean Supply Chain ManagementProcess ControlProcess EngineeringProduct CostingProgram ManagementProject ScheduleScience, Technology, Engineering, and Math (STEM) ApplicationTactical PlanningTechnical CredibilityTechnical ResearchBenefits Pay Range (primary location): €96,000 – €165,025. Italy: €70,700 – €122,015.Annual bonus with target percentage of pay, based on performance.Vacation days.Parental leave (minimum 12 weeks).Bereavement leave.Caregiver leave.Volunteer leave.Well‑being reimbursement.Programs for financial, physical and mental health.Service anniversary and recognition awards.Insurance plans for employees and eligible dependents.This information is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change.