Descrizione:
Overview We are seeking a Postdoctoral Researcher in Computational Genomics to join our team working on the TRANSCAN-3 Seq Per Glio project: "Intraoperative tumour sequencing for personalized loco‑regional drug combination therapy against glioblastoma recurrences". The role offers a unique opportunity to develop novel computational methodologies for real‑time genomic and epigenomic profiling using Oxford Nanopore Technologies (ONT) long‑read sequencing. The position is one‑year renewable, with the start date to be determined, and is based at CTGLab, IIT-CNR, Pisa‑Siena, Italy. Project Description Seq Per Glio is an international consortium (2025‑2028) focused on establishing intraoperative molecular profiling workflows to guide personalized drug combination therapy for glioblastoma. The project integrates real‑time nanopore sequencing of tumor specimens during surgery, multi‑omics data integration (genomics, transcriptomics, epigenomics), clinical decision support for loco‑regional therapy selection, and direct collaboration with neurosurgery centers across Europe. Responsibilities Design and implement computational pipelines for real‑time analysis of Oxford Nanopore long‑read sequencing data, including: Structural variant detection and clonality assessment DNA methylation profiling and tumor classification RNA isoform analysis and fusion detection Integration with clinical genomic databases Develop novel algorithms for: Rapid quality control and data processing optimized for clinical timelines Multi‑omics data integration from nanopore, single‑cell, and imaging data Biomarker identification for therapy response prediction Tumor heterogeneity characterization Collaborate closely with wet‑lab scientists, clinicians, and neurosurgeons to: Translate computational results into actionable clinical insights Establish validation protocols and quality metrics Contribute to standard operating procedures for clinical implementation Contribute to scientific dissemination through publications in high‑impact journals, presentations at international conferences, and consortium reports. About CTGLab CTGLab is a multidisciplinary team specializing in computational methods for multi‑omics integration in cancer genomics. For details on research activities and latest publications, visit #J-18808-Ljbffr